Systems Biology Applied to Immune Safety


We are delighted that you have chosen the Immuno-Safety Tools module to start or enhance your current educational journey in immuno-safety science. This lecture is one in a series of six providing detailed information on tools currently used to evaluate and characterize the status of the immune system in a preclinical setting and is led by Dr. Holden Maecker at Stanford University. Please review the learning objectives below for more information on what you will learn in this lecture.
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Target Audience

This course is intended for the science professional or graduate student looking to learn the fundamental science and key considerations that are examined in immune safety assessment. The advanced topics offered in this module are intended to take a deeper dive into specific scientific areas. These courses are recommended for the more experienced scientist with a firm grasp of the information highlighted in the introduction module.

Learning Objectives

The learner will be able to: 
  • Compare and contrast relevant attributes of at least three assay platforms for systems-level study of immune safety.
  • Give an example of a functional immune readout and how it provides information that a phenotypic assay may not provide.
  • Describe three relevant classes of high-dimensional data analysis algorithms, with at least one example of each.
  • Discuss the difficulties involved with defining the range of “normal” for parameters in the immune system, and how these can be overcome.


Additional Information

Course summary
Available credit: 
  • 1.00 Participation
Course opens: 
Course expires: 

Lectures in this module

Clinical pathology in preclinical immuno-safety assessment
Immunopathology: Evaluation from Discovery to Safety Assessment
TDAR assessments
Cytokine Release Syndrome (CRS)
Systems biology applied to immune safety
Holden T. Maecker, PhD
Stanford University

Available Credit

  • 1.00 Participation


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