Safety Considerations for Oligonucleotides


We are delighted that you have chosen the Therapeutic Modalities module to start or enhance your current educational journey in immuno-safety science. This lecture is one in a series of five providing detailed information on current and/or emerging therapeutics that interact with the immune system and is led by Dr. Padmakumar Narayanan at WAVE Life Sciences. Please review the learning objectives below for more information on what you will learn in this lecture.
If you are new to HESI and would like to learn more about our organization, please take a moment to visit our website at

Target Audience

This course is intended for the science professional or graduate student looking to learn the fundamental science and key consideration that are examined in immune safety assessment. Advanced topics and coursed that take a deeper dive into specific scientific areas will be offered and are recommended for the more experienced scientist who has a firm grasp of the information highlighted in the introduction module.

Learning Objectives

The learner will be able to:
  • Explain the key designs/features and mechanisms that oligonucleotide-based therapies use to modulate targets inaccessible to small and large molecule therapeutics. 
  • Explain and analyze impact of specific oligonucleotide chemistry and design on immunomodulatory/pro-inflammatory potential of oligonucleotides.
  • Evaluate the regulatory perspectives involved in oligonucleotide development for, widely prevalent to rare to ultrarare, genetic diseases.

Additional Information

Course summary
Available credit: 
  • 1.00 Participation
Course opens: 
Course expires: 

Lectures in this module

CAR Therapy
Safety Considerations for Oligonucleotides
CD3-binding (T cell engaging) immune stimulating antibody-based therapies
Gene Therapy
Nonclinical Development of Biologics
Padmakumar Narayanan, DVM, MS, PhD
WAVE Life Sciences

Available Credit

  • 1.00 Participation


Please login or register to take this course.

Required Hardware/software

This platform, Ethos CE, works with most modern web browsers (e.g., Chrome, Internet Explorer, MS Edge, Safari). Contact if you are having any difficulties with this platform.