Immunogenicity characterization tools (ADAs, complement, immune complexes)


We are delighted that you have chosen the Immuno-Safety Tools module to start or enhance your current educational journey in immuno-safety science. This lecture is one in a series of seven providing detailed information on tools currently used to evaluate and characterize the status of the immune system in a preclinical setting. Please review the learning objectives below for more information on what you will learn in this lecture.
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Target Audience

This course is intended for the science professional or graduate student looking to learn the fundamental science and key considerations that are examined in immune safety assessment. The advanced topics offered in this module are intended to take a deeper dive into specific scientific areas. These courses are recommended for the more experienced scientist with a firm grasp of the information highlighted in the introduction module.

Learning Objectives

The learner will:
  • Understand the different tests used to predict immunogenicity of biotherapeutics.
  • Evaluate limits of non-clinical species for immunogenicity prediction.
  • Have comprehension of immunogenicity prediction models and translation to the clinic.
  • Have a comprehensive overview of ADA in the clinic: measurement and consequences for clinical response, PK and safety.
Course summary
Available credit: 
  • 0.50 Participation
Course opens: 
Course expires: 

Lectures in this module

Clinical pathology in preclinical immuno-safety assessment
Immunopathology: Evaluation from Discovery to Safety Assessment
TDAR assessments
Cytokine Release Syndrome (CRS)
Systems biology applied to immune safety
Immunogenicity characterization tools (ADAs, complement, immune complexes)
Marc Pallardy
Pharmacological faculty
Université Paris-Saclay

Available Credit

  • 0.50 Participation


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