Explain the key designs/features and mechanisms that oligonucleotide-based therapies use to modulate targets inaccessible to small and large molecule therapeutics. 

Explain and analyze impact of specific oligonucleotide chemistry and design on immunomodulatory/pro-inflammatory potential of oligonucleotides 

Evaluate the regulatory perspectives involved in oligonucleotide development for, widely prevalent to rare to ultrarare, genetic diseases